1: J Dermatol Sci 2001 Nov;27(3):162-9

Return to Purdey home page Last updated 20/10/04

Linked References to peer reviewed papers on TSEs and many health topics.

Most links are to abstracts, some full texts are also available free, others by subscription or via the Science library at the British Library, Euston Rd, London. A therapeutic approach is implicit in many of the papers ie on page 2 there's much on poor sulphur metabolism and disease (sulphoxidation pathway).
These papers are not the last word on these diseases and I intend to continue expanding these lists as I come across interesting/useful material.
Visitors to this site should always discuss any therapeutic ideas contained on this site with a suitably qualified person before embarking on or giving up a course of therapy.

Page 1: UV, Prions/metals, CJD epidemiology, ozone, metals and life, Occupational exposures, pesticides/organophosphates and ecogenetics, Pesticides and endocrine disruption, Chronic Fatigue Syndrome, Mycoplasma, Gulf War syndrome, mercury, manganese, silicone breast implants, Environmental studies/pollution

Page 2: Parkinsons, Carbon disulphide, cancer, mobile phones/magnetic fields, Radon, autism, ADHD, ulcerative colitis, HIV, migraine, rheumatoid arthritis, Chinese herbs/allergy, Motor neurone disease, Alzheimers, Amyotrophic lateral sclerosis, Guam diseases, systemic lupus, schizophrenia, homeopathy, Sudden Infant death syndrome, Fluoride

Page 3: Nerve regeneration, Stem cell research, Ecogenetics, Vitamins and minerals, Selenium, Co-enzyme Q10, Magnesium, Guillain Barre syndrome, Meniere's syndrome, Ecstasy, oxidative stress, Nitric oxide, immunology, Dioxins and PCBs, Aplastic anaemia and pesticides, Infrasound acoustic diseases, Multiple Sclerosis, Asbestos/mineral fibre.

UV

Ryoo YW, Suh SI, Mun KC, Kim BC, Lee KS. The effects of the melatonin on ultraviolet-B irradiated cultured dermal fibroblasts. J Dermatol Sci 2001 Nov;27(3):162-9

Fischer TW, Scholz G, Knoll B, Hipler UC, Elsner P Melatonin reduces UV-induced reactive oxygen species in a dose-dependent manner in IL-3-stimulated leukocytes. J Pineal Res 2001 Aug;31(1):39-45

Elleder M, Borovansky J. Autofluorescence of melanins induced by ultraviolet radiation and near ultraviolet light. A histochemical and biochemical study. Histochem J. 2001 May;33(5):273-81

Oya-Ohta Y, Ueda A, Ochi T, Harada M, Yamamoto K. The biological activity of hydrogen peroxide VII. L-Histidine increases incorporation of H(2)O(2) into cells and enhances formation of 8-oxodeoxyguanosine by UV-C plus H(2)O(2) but not by H(2)O(2) alone. Mutat Res 2001 Jul 1;478(1-2):119-27
Joshi PC. Copper(II) as an efficient scavenger of singlet molecular oxygen. Indian J Biochem Biophys. 1998 Aug;35(4):208-15.
Paretzoglou A, Stockenhuber C, Kirk SH, Ahmad SI. Generation of reactive oxygen species from the photolysis of histidine by near-ultraviolet light: effects on T7 as a model biological system. J Photochem Photobiol B. 1998 May 15;43(2):101-5.

Prions

Mendez OE, Shang J, Jungreis CA, Kaufer DI.Diffusion-weighted MRI in Creutzfeldt-Jakob disease: a better diagnostic marker than CSF protein 14-3-3?
J Neuroimaging. 2003 Apr;13(2):147-51. Review.
Bounias M, Purdey M. Transmissible spongiform encephalopathies: a family of etiologically complex diseases--a review. Sci Total Environ. 2002 Oct 7;297(1-3):1-19.

Milhavet O, Lehmann S. Oxidative stress and the prion protein in transmissible spongiform encephalopathies.
Brain Res Brain Res Rev. 2002 Feb;38(3):328-39. Review.

David R. Brown Copper and prion disease Brain Research Bulletin, 2001,55:2:165-173. Full Text
Brown DR, Nicholas RS, Canevari L. Lack of prion protein expression results in a neuronal phenotype sensitive to stress.
J Neurosci Res. 2002 Jan 15;67(2):211-24.
Brown DR. BSE did not cause variant CJD: an alternative cause related to post-industrial environmental contamination. Med Hypotheses. 2001 Nov;57(5):555-60.
Daniels M, Cereghetti GM, Brown DR. Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations.
Eur J Biochem. 2001 Dec;268(23):6155-64.

Wong BS, Chen SG, Colucci M, Xie Z, Pan T, Liu T, Li R, Gambetti P, Sy MS, Brown DR.

Aberrant metal binding by prion protein in human prion disease. J Neurochem. 2001 Sep;78(6):1400-8.

Brown DR, Besinger A. Prion protein expression and superoxide dismutase activity. Biochem J. 1998 Sep 1;334 ( Pt 2):423-9

D.R. Brown et al .Consequences of manganese replacement of copper for prion protein function and proteinase resistance The EMBO Journal Vol 19 No 6 pp 1180-1186. 2000. Full text available free

Jackson GS, Murray I, Hosszu LL, Gibbs N, Waltho JP, Clarke AR, Collinge J. Location and properties of metal-binding sites on the human prion protein.

Lawler S. Farmer's research goes against the grain. Trends Cell Biol. 2001 Mar;11(3):110.

Requena JR, Groth D, Legname G, Stadtman ER, Prusiner SB, Levine RL.Copper-catalyzed oxidation of the recombinant SHa(29-231) prion protein. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7170-5

Jobling MF, Huang X, Stewart LR, Barnham KJ, Curtain C, Volitakis I, Perugini M, White AR, Cherny RA, Masters CL, Barrow CJ, Collins SJ, Bush AI, Cappai R.Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126. Biochemistry. 2001 Jul 10;40(27):8073-84.

White AR, Collins SJ, Maher F, Jobling MF, Stewart LR, Thyer JM, Beyreuther K, Masters CL, Cappai R. Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity. Am J Pathol. 1999 Nov;155(5):1723-30

Gaubert S, Bouchaut M, Brumas V, Berthon G.Copper--ligand interactions and the physiological free radical processes. Part 3. Influence of histidine, salicylic acid and anthranilic acid on copper-driven Fenton chemistry in vitro. Free Radic Res. 2000 May;32(5):451-61

McMahon HE, Mange A, Nishida N, Creminon C, Casanova D, Lehmann S. Cleavage of the amino terminus of the prion protein by reactive oxygen species.

J Biol Chem. 2001 Jan 19;276(3):2286-91

Hidalgo J, Aschner M, Zatta P, Vasak M. Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull. 2001 May 15;55(2):133-45. Review.

Cagampang FR, Whatley SA, Mitchell AL, Powell JF, Campbell IC, Coen CW. Circadian regulation of prion protein messenger RNA in the rat forebrain: a widespread and synchronous rhythm. Neuroscience. 1999;91(4):1201-4.

Whatley SA, Curti D, Das Gupta F, Ferrier IN, Jones S, Taylor C, Marchbanks RM. Superoxide, neuroleptics and the ubiquinone and cytochrome b5 reductases in brain and lymphocytes from normals and schizophrenic patients. Mol Psychiatry. 1998 May;3(3):227-37.

Gordon I, Abdulla EM, Campbell IC, Whatley SA. Phosmet induces up-regulation of surface levels of the cellular prion protein. Neuroreport. 1998 May 11;9(7):1391-5.

Whatley SA, Powell JF, Politopoulou G, Campbell IC, Brammer MJ, Percy NS. Regulation of intracellular free calcium levels by the cellular prion protein. Neuroreport. 1995 Nov 27;6(17):2333-7.

Brown DR. Microglia and prion disease. Microsc Res Tech. 2001 Jul 15;54(2):71-80. Review.

Guentchev M, Wanschitz J, Voigtlander T, Flicker H, Budka H .Selective neuronal vulnerability in human prion diseases. Fatal familial insomnia differs from other types of prion diseases. Am J Pathol. 1999 Nov;155(5):1453-7.

Guentchev M, Groschup MH, Kordek R, Liberski PP, Budka H. Severe, early and selective loss of a subpopulation of GABAergic inhibitory neurons in experimental transmissible spongiform encephalopathies. Brain Pathol. 1998 Oct;8(4):615-23.

Voigtlander T, Kloppel S, Birner P, Jarius C, Flicker H, Verghese-Nikolakaki S, Sklaviadis T, Guentchev M, Budka H. Marked increase of neuronal prion protein immunoreactivity in Alzheimer's disease and human prion diseases. Acta Neuropathol (Berl). 2001 May;101(5):417-23.

Guentchev M, Voigtlander T, Haberler C, Groschup MH, Budka H. Evidence for oxidative stress in experimental prion disease.
Neurobiol Dis. 2000 Aug;7(4):270-3.

Choi SI, Ju WK, Choi EK, Kim J, Lea HZ, Carp RI, Wisniewski HM, Kim YS. Mitochondrial dysfunction induced by oxidative stress in the brains of hamsters infected with the 263 K scrapie agent. Acta Neuropathol (Berl). 1998 Sep;96(3):279-86.

Karlin S, Zhu ZY, Karlin KD. The extended environment of mononuclear metal centers in protein structures. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14225-30.

CJD/epidemiology

Mitrova E, Huncaga S, Hocman G, Nyitrayova O, Tatara M. "Clusters" of CJD in Slovakia: the first laboratory evidence of scrapie.
Eur J Epidemiol. 1991 Sep;7(5):520-3. Review.

Mitrova E, Bronis M. "Clusters" of CJD in Slovakia: the first statistically significant temporo-spatial accumulations of rural cases. Eur J Epidemiol. 1991 Sep;7(5):450-6.

Mitrova E. Some new aspects of CJD epidemiology in Slovakia. Eur J Epidemiol. 1991 Sep;7(5):439-49.

Ozone/H2O2

Rivas J, Rodriguez E, Beltran FJ, Garcia-Araya JF, Alvarez P. Homogenous catalyzed ozonation of simazine. Effect of Mn(II) and Fe(II).
J Environ Sci Health B. 2001 May;36(3):317-30.

Andreozzi R, Caprio V, Marotta R, Tufano V. Kinetic modeling of pyruvic acid ozonation in aqueous solutions catalyzed by Mn(II) and Mn(IV) ions.
Water Res. 2001 Jan;35(1):109-20.

Weller BL, Witschi H, Pinkerton KE. Quantitation and localization of pulmonary manganese superoxide dismutase and tumor necrosis factor alpha following exposure to ozone and nitrogen dioxide. Toxicol Sci. 2000 Apr;54(2):452-61.

McDonald RJ, Usachencko J.McDonald RJ, Usachencko J. Neutrophils injure bronchial epithelium after ozone exposure. Inflammation 1999 Feb;23(1):63-73

Pinkerton KE, Weller BL, Menache MG, Plopper CG. Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part XIII. A comparison of changes in the tracheobronchial epithelium and pulmonary acinus in male rats at 3 and 20 months.
Res Rep Health Eff Inst. 1998 Jun;(65):1-32; discussion 33-7.

Weller BL, Crapo JD, Slot J, Posthuma G, Plopper CG, Pinkerton KE. Site- and cell-specific alteration of lung copper/zinc and manganese superoxide dismutases by chronic ozone exposure. Am J Respir Cell Mol Biol. 1997 Nov;17(5):552-60.

Quinlan T, Spivack S, Mossman BT. Regulation of antioxidant enzymes in lung after oxidant injury. Environ Health Perspect. 1994 Jun;102 Suppl 2:79-87. Review.

Beltran FJ, Rivas J, Acedo B. Atrazine removal by ozonation processes in surface waters. J Environ Sci Health B. 1999 May;34(3):449-68.

Peralta C, Leon OS, Xaus C, Prats N, Jalil EC, Planell ES, Puig-Parellada P, Gelpi E, Rosello-Catafau J.

Protective effect of ozone treatment on the injury associated with hepatic ischemia-reperfusion: antioxidant-prooxidant balance.

Fukunaga K, Nakazono N, Suzuki T, Takama K.

Mechanism of oxidative damage to fish red blood cells by ozone. IUBMB Life. 1999 Dec;48(6):631-4.

Valacchi G, Bocci V. Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells.
Mediators Inflamm. 2000;9(6):271-6.

Pellinen R, Palva T, Kangasjarvi J. Short communication: subcellular localization of ozone-induced hydrogen peroxide production in birch (Betula pendula) leaf cells. Plant J. 1999 Nov;20(3):349-56.

Balcioglu IA, Arslan I. Partial oxidation of reactive dyestuffs and synthetic textile dye-bath by the O3 and O3/H2O2 processes. Water Sci Technol. 2001;43(2):221-8.

Szpyrkowicz L, Juzzolino C, Kaul SN. A comparative study on oxidation of disperse dyes by electrochemical process, ozone, hypochlorite and Fenton reagent.
Water Res. 2001 Jun;35(9):2129-36.

Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M, Lim JT, Faget KY, Muffat JA, Scarpa RC, Chylack LT Jr, Bowden EF, Tanzi RE, Bush AI. 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin croslinking by metal ion reduction.
Biochemistry. 2000 Jun 20;39(24):7266-75.

Sterner-Kock A, Braun RK, van der Vliet A, Schrenzel MD, McDonald RJ, Kabbur MB, Vulliet PR, Hyde DM. Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils. J Leukoc Biol. 1999 Jun;65(6):834-40.

Metals and life
Leung TK, Lim L, Lai JC. Differential effects of metal ions on type A and type B monoamine oxidase activities in rat brain and liver mitochondria. Metab Brain Dis. 1992 Sep;7(3):139-46.

Kolesnikov MP, Egorov IA. Metalloporphyrins and molecular complexes of amino acids with porphyrins in juvenile volcanic ash. Orig Life. 1979 Sep;9(4):267-77.

Kasprzak KS. Possible role of oxidative damage in metal-induced carcinogenesis.
Cancer Invest. 1995;13(4):411-30. Review.

Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 1999 Jun 15;38(24):7609-16.

Atwood CS, Moir RD, Huang X, Scarpa RC, Bacarra NM, Romano DM, Hartshorn MA, Tanzi RE, Bush AI. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem. 1998 May 22;273(21):12817-26.

Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, Bowden EF, Masters CL, Fairlie DP, Tanzi RE, Bush AI. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem. 1999 Dec 24;274(52):37111-6.

McKenzie D, Bartz J, Mirwald J, Olander D, Marsh R, Aiken J. Reversibility of scrapie inactivation is enhanced by copper. J Biol Chem. 1998 Oct 2;273(40):25545-7.

Atwood CS, Huang X, Khatri A, Scarpa RC, Kim YS, Moir RD, Tanzi RE, Roher AE, Bush AI

Copper catalyzed oxidation of Alzheimer Abeta. Cell Mol Biol (Noisy-le-grand) 2000 Jun;46(4):777-83

Bush AI. Metals and neuroscience. Current Opinion Chem Biol. 2000 Apr;4 (2):184-91. Review

Choi SY, Kim YH, Lee YK, Kim KT. Chlorpromazine inhibits store-operated calcium entry and subsequent noradrenaline secretion in PC12 cells. Br J Pharmacol. 2001 Jan;132(2):411-8.

Borza DB, Morgan WT. Histidine-proline-rich glycoprotein as a plasma pH sensor. Modulation of its interaction with glycosaminoglycans by ph and metals. J Biol Chem. 1998 Mar 6;273(10):5493-9.

Jobling MF, Huang X, Stewart LR, Barnham KJ, Curtain C, Volitakis I, Perugini M, White AR, Cherny RA, Masters CL, Barrow CJ, Collins SJ, Bush AI, Cappai R. Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126. Biochemistry. 2001 Jul 10;40(27):8073-84.

Ross GM, Shamovsky IL, Woo SB, Post JI, Vrkljan PN, Lawrance G, Solc M, Dostaler SM, Neet KE, Riopelle RJ. The binding of zinc and copper ions to nerve growth factor is differentially affected by pH: implications for cerebral acidosis. J Neurochem. 2001 Aug;78(3):515-23

Suzuki K, Miura T, Takeuchi H Inhibitory effect of copper(II) on zinc(II)-induced aggregation of amyloid beta-peptide. Biochem Biophys Res Commun. 2001 Jul 27;285(4):991-6.
Kurahashi T, Miyazaki A, Suwan S, Isobe M. Extensive investigations on oxidized amino acid residues in H(2)O(2)-treated Cu,Zn-SOd protein with LC-ESI-Q-TOF-MS, MS/MS for the determination of the copper-binding site. J Am Chem Soc. 2001 Sep 26;123(38):9268-78.
Tokarnia CH, Dobereiner J, Peixoto PV, Moraes SS. Outbreak of copper poisoning in cattle fed poultry litter. Vet Hum Toxicol. 2000 Apr;42(2):92-5.
Gummow B. Experimentally induced chronic copper toxicity in cattle. Onderstepoort J Vet Res. 1996 Dec;63(4):277-88.
Midorikawa K, Kawanishi S. Superoxide dismutases enhance H2O2-induced DNA damage and alter its site specificity. FEBS Lett. 2001 Apr 27;495(3):187-90.
Siu AW, Cheung JP, To CH, Chan EK, Chan JK, Cheung JC. N-acetyl-serotonin reduces copper (I) ion-induced lipid peroxidation in bovine retinal homogenates. Acta Ophthalmol Scand. 2001 Feb;79(1):69-71
Damiani E, Kalinska B, Canapa A, Canestrari S, Wozniak M, Olmo E, Greci L. The effects of nitroxide radicals on oxidative DNA damage. Free Radic Biol Med. 2000 Apr 15;28(8):1257-65
Kim RH, Park JE, Park JW. Ceruloplasmin enhances DNA damage induced by hydrogen peroxide in vitro. Free Radic Res. 2000 Jul;33(1):81-9.
Banton MI, Nicholson SS, Jowett PL, Brantley MB, Boudreaux CL. Copper toxicosis in cattle fed chicken litter. J Am Vet Med Assoc. 1987 Oct 1;191(7):827-8.
MacPherson A, Milne EM, Macpherson AJ. Copper poisoning in ewes.Vet Rec. 1997 Dec 13;141(24):631. No abstract available
Sullivan JM, Janovitz EB, Robinson FR.Copper toxicosis in veal calves. J Vet Diagn Invest. 1991 Apr;3(2):161-4.
Stogdale L. Chronic copper poisoning in dairy cows. Aust Vet J. 1978 Mar;54(3):139-41.
Weber CE. Corticosteroid regulation of electrolytes. J Theor Biol. 1983 Oct 7;104(3):443-9.

Occupational exposures

Steffen C, Auclerc MF, Auvrignon A, Baruchel A, Kebaili K, Lambilliotte A, Leverger G, Sommelet D, Vilmer E, Hemon D, Clavel J. Acute childhood leukaemia and environmental exposure to potential sources of benzene and other hydrocarbons; a case-control study. Occup Environ Med. 2004 Sep;61(9):773-8.
Phillips TM Assessing environmental exposure in children: immunotoxicology screening. J Expo Anal Environ Epidemiol. 2000 Nov-Dec;10(6 Pt 2):769-75.
Hastings L, Evans JE Olfactory primary neurons as a route of entry for toxic agents into the CNS. Neurotoxicology. 1991 Winter;12(4):707-14.
Krebs JM, Park RM, Boal WL. A neurological disease cluster at a manufacturing plant. Arch Environ Health. 1995 May-Jun;50(3):190-5.
Azaroff LS, Neas LM. Acute health effects associated with nonoccupational pesticide exposure in rural El Salvador. Environ Res. 1999 Feb;80(2 Pt 1):158-64.
Azaroff LS. Biomarkers of exposure to organophosphorous insecticides among farmers' families in rural El Salvador: factors associated with exposure. Environ Res. 1999 Feb;80(2 Pt 1):138-47.
Fiedler N, Kipen H, Kelly-McNeil K, Fenske R. Long-term use of organophosphates and neuropsychological performance. Am J Ind Med. 1997 Nov;32(5):487-96.
Compston JE, Vedi S, Stephen AB, Bord S, Lyons AR, Hodges SJ, Scammell BE. Reduced bone formation after exposure to organophosphates. Lancet. 1999 Nov 20;354(9192):1791-2.
Blain PG. Adverse health effects after low level exposure to organophosphates. Occup Environ Med. 2001 Nov;58(11):689-90. No abstract available.
Leznoff A. Re: Davidoff et al. Development of multiple chemical sensitivities in laborers after acute gasoline fume exposure in an underground tunnelling operation. Arch Environ Health. 1999 Jul-Aug;54(4):302-3. No abstract available.
Misra UK, Nag D, Misra NK, Mehra MK, Ray PK. Some observations on the macula of pesticide workers. Hum Toxicol. 1985 Mar;4(2):135-45.
Thrasher JD, Broughton A, Madison R. Immune activation and autoantibodies in humans with long-term inhalation exposure to formaldehyde. Arch Environ Health. 1990 Jul-Aug;45(4):217-23.
Cherry N, Labreche F, Collins J, Tulandi T. Occupational exposure to solvents and male infertility.
Occup Environ Med. 2001 Oct;58(10):635-40.
Meyer JD, Holt DL, Chen Y, Cherry NM, McDonald JC. SWORD '99: surveillance of work-related and occupational respiratory disease in the UK. Occup Med (Lond). 2001 May;51(3):204-8.
Uversky VN, Li J, Fink AL. Metal-triggered structural transformations, aggregation and fibrillation of human alpha-synuclein. A possible molecular link between parkinson's disease and heavy metal exposure. J Biol Chem. 2001 Sep 11 [epub ahead of print
Godzik S, Szdzuj J, Poborski P. Environmental pollution in south Poland. Sources and effects. Folia Med Cracov. 1993;34(1-4):9-18.
Lesser SH, Weiss SJ. Art hazards. Am J Emerg Med. 1995 Jul;13(4):451-8. Review.
Grabo TN. Unknown toxic exposures. Arts and crafts materials. AAOHN J. 1997 Mar;45(3):124-30. Review.
Kristensen P, Johansen S. [Chemical occupational environment of artists (painting, graphic, sculpture]
Tidsskr Nor Laegeforen. 1994 Nov 10;114(27):3184-7. Norwegian.
Dorevitch S, Babin A. Health hazards of ceramic artists. Occup Med. 2001 Oct-Dec;16(4):563-75, iii. Review.
Rosenthal J, Forst L. Health hazards of photography. Occup Med. 2001 Oct-Dec;16(4):577-82, iv. Review.
Spandorfer M, Curtiss D, Snyder JW. Health hazards in drawing and painting. Occup Med. 2001 Oct-Dec;16(4):535-55, iii. Review.
Guidotti TL, Audette RJ, Martin CJ. Interpretation of the trace metal analysis profile for patients occupationally exposed to metals. Occup Med (Lond). 1997 Nov;47(8):497-503.
Weiss SJ, Lesser SH. Hazards associated with metalworking by artists. South Med J. 1997 Jul;90(7):665-71.
Lu PC. A health hazard assessment in school arts and crafts. J Environ Pathol Toxicol Oncol. 1992 Jan-Feb;11(1):12-7.
Saito H, Ojima J, Takaya M, Iwasaki T, Hisanaga N, Tanaka S, Arito H. Laboratory measurement of hazardous fumes and gases at a point corresponding to breathing zone of welder during a CO2 arc welding. Ind Health. 2000 Jan;38(1):69-78.
Korczynski RE. Occupational health concerns in the welding industry. Appl Occup Environ Hyg. 2000 Dec;15(12):936-45.
Vojdani A, Namatalla G, Brautbar N. Methyl tertiary-butyl ether antibodies among gasoline service station attendants. Ann N Y Acad Sci. 1997 Dec 26;837:96-104.
Lisiewicz J. Immunotoxic and hematotoxic effects of occupational exposures. Folia Med Cracov. 1993;34(1-4):29-47.

OP's, and other pesticides

Burrell R. Human immune toxicity. Mol Aspects Med. 1993;14(1):1-81. Review
Yen DH, Chan JY, Tseng HP, Huang CI, Lee CH, Chan SH, Chang AY. Depression of mitochondrial respiratory enzyme activity in rostral ventrolateral medulla during acute mevinphos intoxication in the rat. Shock. 2004 Apr;21(4):358-63.
Verhulst L, Waggie Z, Hatherill M, Reynolds L, Argent A. Presentation and outcome of severe anticholinesterase insecticide poisoning. Arch Dis Child. 2002 May;86(5):352-5.
Kapsenberg ML. Chemicals and proteins as allergens and adjuvants. Toxicol Lett. 1996 Aug;86(2-3):79-83. Review.
Grisaru D, Sternfeld M, Eldor A, Glick D, Soreq H. Structural roles of acetylcholinesterase variants in biology and pathology. Eur J Biochem. 1999 Sep;264(3):672-86. Review.
Grisaru D, Lev-Lehman E, Shapira M, Chaikin E, Lessing JB, Eldor A, Eckstein F, Soreq H. Human osteogenesis involves differentiation-dependent increases in the morphogenically active 3' alternative splicing variant of acetylcholinesterase. Mol Cell Biol. 1999 Jan;19(1):788-95.
Brown MA, Brix KA. Review of health consequences from high-, intermediate- and low-level exposure to organophosphorus nerve agents. J Appl Toxicol. 1998 Nov-Dec;18(6):393-408. Review.
Compston JE, Vedi S, Stephen AB, Bord S, Lyons AR, Hodges SJ, Scammell BE. Reduced bone formation after exposure to organophosphates. Lancet. 1999 Nov 20;354(9192):1791-2
Liu PS, Kao LS, Lin MK. Organophosphates inhibit catecholamine secretion and calcium influx in bovine adrenal chromaffin cells. Toxicology. 1994 May 31;90(1-2):81-91.
Latendresse JR, Azhar S, Brooks CL, Capen CC. Pathogenesis of cholesteryl lipidosis of adrenocortical and ovarian interstitial cells in F344 rats caused by tricresyl phosphate and butylated triphenyl phosphate. Toxicol Appl Pharmacol. 1993 Oct;122(2):281-9.
Misra UK, Prasad M, Pandey CM. A study of cognitive functions and event related potentials following organophosphate exposure. Electromyogr Clin Neurophysiol. 1994 Jun;34(4):197-203.
Wang AG, Liu RS, Liu JH, Teng MM, Yen MY. Positron emission tomography scan in cortical visual loss in patients with organophosphate intoxication. Ophthalmology. 1999 Jul;106(7):1287-91.
Misra UK, Nag D, Misra NK, Mehra MK, Ray PK. Some observations on the macula of pesticide workers.
Hum Toxicol. 1985 Mar;4(2):135-45.
Wang AG, Liu RS, Liu JH, Teng MM, Yen MY. Positron emission tomography scan in cortical visual loss in patients with organophosphate intoxication. Ophthalmology. 1999 Jul;106(7):1287-91.
Sickles DW, Stone JD, Friedman MA. Fast axonal transport: a site of acrylamide neurotoxicity?
Neurotoxicology. 2002 Jul;23(2):223-51.
Stone JD, Peterson AP, Eyer J, Oblak TG, Sickles DW. Neurofilaments are nonessential to the pathogenesis of toxicant-induced axonal degeneration. J Neurosci. 2001 Apr 1;21(7):2278-87.
Stone JD, Terry AV Jr, Pauly JR, Prendergast MA, Buccafusco JJ. Protractive effects of chronic treatment with an acutely sub-toxic regimen of diisopropylflurophosphate on the expression of cholinergic receptor densities in rats. Brain Res. 2000 Nov 3;882(1-2):9-18.
Brown HR, Sharma RP. Synaptosomal adenosine triphosphatase (ATPase) inhibition by organophosphates.
Experientia. 1976 Dec 15;32(12):1540-2.
Dierkes-Tizek U, Glaser U, Oldiges H, Hettwer H. [The effect of organophosphates on heart ATPase in the rat] Arzneimittelforschung. 1984;34(6):671-8. German.
Lehning EJ, Tanaka D Jr, Bursian SJ. Triphenyl phosphite and diisopropylphosphorofluoridate produce separate and distinct axonal degeneration patterns in the central nervous system of the rat. Fundam Appl Toxicol. 1996 Jan;29(1):110-8.
Husain K, Vijayaraghavan R. DFP induced changes in acetylcholinesterase activity and glycogen level in certain brain regions of mice. Indian J Physiol Pharmacol. 1989 Oct-Dec;33(4):250-2.
Dulaney MD Jr, Rockhold RW, Porter AC, Hoskins B, Ho IK. Changes in drinking activity, urine volume and urinary electrolyte excretion after intracerebroventricular administration of diisopropylfluorophosphate.
J Pharmacol Exp Ther. 1989 Jul;250(1):202-9.
Smolen A, Smolen TN, Han PC, Collins AC. Sex differences in the recovery of brain acetylcholinesterase activity following a single exposure to DFP. Pharmacol Biochem Behav. 1987 Apr;26(4):813-20.
Schwartz RD, Kellar KJ. In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs. J Neurochem. 1985 Aug;45(2):427-33.
Robinson SE, Rice MA, Hambrecht KL. Effect of intrastriatal injection of diisopropylfluorophosphate on acetylcholine, dopamine, and serotonin metabolism. J Neurochem. 1986 May;46(5):1632-8.
Parke DV. Mechanisms of chemical toxicity--a unifying hypothesis. Regul Toxicol Pharmacol. 1982 Dec;2(4):267-86. Parke DV. Activation mechanisms to chemical toxicity. Arch Toxicol. 1987;60(1-3):5-15. Review.
Rajagopalan S, Koper O, Decker S, Klabunde KJ. Nanocrystalline metal oxides as destructive adsorbents for organophosphorus compounds at ambient temperatures. Chemistry. 2002 Jun 3;8(11):2602-7.
Decker SP, Klabunde JS, Khaleel A, Klabunde KJ. Catalyzed destructive adsorption of environmental toxins with nanocrystalline metal oxides. Fluoro-, chloro-, bromocarbons, sulfur, and organophosophorus compounds. Environ Sci Technol. 2002 Feb 15;36(4):762-8.
Lucas E, Decker S, Khaleel A, Seitz A, Fultz S, Ponce A, Li W, Carnes C, Klabunde KJ. Nanocrystalline metal oxides as unique chemical reagents/sorbents. Chemistry. 2001 Jun 18;7(12):2505-10.
Whyatt RM, Camann DE, Kinney PL, Reyes A, Ramirez J, Dietrich J, Diaz D, Holmes D, Perera FP. Residential pesticide use during pregnancy among a cohort of urban minority women. Environ Health Perspect. 2002 May;110(5):507-14.
Whyatt RM, Barr DB. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study.
Environ Health Perspect. 2001 Apr;109(4):417-20.
Dean TN, Kakkanaiah VN, Nagarkatti M, Nagarkatti PS. Immunosuppression by aldicarb of T cell responses to antigen-specific and polyclonal stimuli results from defective IL-1 production by the macrophages. Toxicol Appl Pharmacol. 1990 Dec;106(3):408-17.
Dean TN, Selvan RS, Misra HP, Nagarkatti M, Nagarkatti PS. Aldicarb treatment inhibits the stimulatory activity of macrophages without affecting the T-cell responses in the syngeneic mixed lymphocyte reaction. Int J Immunopharmacol. 1990;12(3):337-48.
Rahman MF, Siddiqui MK, Jamil K. Biochemical alterations induced by a new phosphorothionate (RPR-II) in tissues of male and female rats. Indian J Exp Biol. 1999 Jun;37(6):546-52.
Dettbarn WD. Pesticide induced muscle necrosis: mechanisms and prevention. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 2):S18-26
Tiwari RK, Bandyopadhyay SK, Chatterjee K, Mitra A, Banerjee A, Chatterjee GC. Effects of high dose application of lindane to rats and influence of L-ascorbic acid supplementation. Int J Vitam Nutr Res. 1982;52(4):448-55.
Gajewski D, Katkiewicz M Activity of certain enzymes and histomorphological changes in subacute intoxication of rats with selected organophosphates. Acta Physiol Pol. 1981 Sep-Oct;32(5):507-20.
Kisielinski T, Gajewski D, Gidynska T, Owczarczyk H. Antiesterase activity of chlorphenvinphos and phospholine in certain rat tissues after administration by different routes. Acta Physiol Pol. 1980 May-Jun;31(3):279-88.
Gajewski D. Acetylcholinesterase activity in several rat liver cell fractions after repeated poisoning with some organophosphates. Acta Physiol Pol. 1980 Sep-Oct;31(5):575-80.
Bendahou N, Bounias M, Fleche C Toxicity of cypermethrin and fenitrothion on the hemolymph carbohydrates, head acetylcholinesterase, and thoracic muscle Na+, K+-ATPase of emerging honeybees (Apis mellifera mellifera. L). Ecotoxicol Environ Saf. 1999 Oct;44(2):139-46.
Kefuss J, M'Diaye K, Bounias M, Vanpoucke J, Ecochard J. Biochemical effects of high intensity constant magnetic fields on worker honey bees. Bioelectromagnetics. 1999;20(2):117-22.
Richards P, Johnson M, Ray D, Walker C. Novel protein targets for organophosphorus compounds. Chem Biol Interact. 1999 May 14;119-120:503-11
Ray DE. Chronic effects of low level exposure to anticholinesterases--a mechanistic review. Toxicol Lett. 1998 Dec 28;102-103:527-33. Review.
Ray DE, Richards PG. The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol Lett. 2001 Mar 31;120(1-3):343-51. Review.
Fournier L, Musard D, Lecorsier A. Lymphocyte esterases and hydroxylases in neurotoxicology. Vet Hum Toxicol. 1996 Jun;38(3):190-5.
Costa LG. Basic toxicology of pesticides. Occup Med. 1997 Apr-Jun;12(2):251-68. Review.
Handy RD, Abd-El Samei HA, Bayomy MF, Mahran AM, Abdeen AM, El-Elaimy EA. Chronic diazinon exposure: pathologies of spleen, thymus, blood cells, and lymph nodes are modulated by dietary protein or lipid in the mouse. Toxicology. 2002 Mar 5;172(1):13-34.
Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE.Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics. 2000 Dec;10(9):767-79.

Cherry N, Mackness M, Durrington P, Povey A, Dippnall M, Smith T, Mackness B. Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip.
Lancet. 2002 Mar 2;359(9308):763-4. http://www.thelancet.com/search/search.isa Full text

Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG. Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). Neurotoxicology. 2000 Feb-Apr;21(1-2):91-100. Review.

Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism.
Chem Biol Interact. 1999 May 14;119-120:429-38. Review.

Furlong CE, Li WF, Costa LG, Richter RJ, Shih DM, Lusis AJ. Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism. Neurotoxicology. 1998 Aug-Oct;19(4-5):645-50.

Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis.Nature. 1998 Jul 16;394(6690):284-7.

Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG The PON1 gene and detoxication. Neurotoxicology. 2000 Aug;21(4):581-7.
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Yagle K, Costa LG. Effects of organophosphate exposure on muscarinic acetylcholine receptor subtype mRNA levels in the adult rat. Neurotoxicology. 1996 Summer;17(2):523-30.

Fernando JC, Hoskins B, Ho IK. Effect on striatal dopamine metabolism and differential motor behavioral tolerance following chronic cholinesterase inhibition with diisopropylfluorophosphate. Pharmacol Biochem Behav. 1984 Jun;20(6):951-7.

Fernando JC, Hoskins BH, Ho IK. A striatal serotonergic involvement in the behavioural effects of anticholinesterase organophosphates. Eur J Pharmacol. 1984 Feb 10;98(1):129-32.
Ho IK, Fernando JC, Sivam SP, Hoskins B. Roles of dopamine and GABA in neurotoxicity of organophosphorus cholinesterase inhibitors. Proc West Pharmacol Soc. 1984;27:177-80. No abstract available.
Seifert J, Pewnim T. Alteration of mice L-tryptophan metabolism by the organophosphorous acid triester diazinon. Biochem Pharmacol. 1992 Dec 1;44(11):2243-50.
Pewnim T, Seifert J. Structural requirements for altering the L-tryptophan metabolism in mice by organophosphorous and methylcarbamate insecticides. Eur J Pharmacol. 1993 Oct 1;248(3):237-41.
Seifert J. Toxicologic significance of the hyperglycemia caused by organophosphorous insecticides. Bull Environ Contam Toxicol. 2001 Oct;67(4):463-9. No abstract available.
Waddell BL, Zahm SH, Baris D, Weisenburger DD, Holmes F, Burmeister LF, Cantor KP, Blair A. Agricultural use of organophosphate pesticides and the risk of non-Hodgkin's lymphoma among male farmers (United States). Cancer Causes Control. 2001 Aug;12(6):509-17.
Hai DQ, Varga SI, Matkovics B. Organophosphate effects on antioxidant system of carp (Cyprinus carpio) and catfish (Ictalurus nebulosus). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997 May;117(1):83-8
Moretto A, Lotti M. Poisoning by organophosphorus insecticides and sensory neuropathy.
J Neurol Neurosurg Psychiatry. 1998 Apr;64(4):463-8.
Lotti M, Moretto A, Capodicasa E, Bertolazzi M, Peraica M, Scapellato ML. Interactions between neuropathy target esterase and its inhibitors and the development of polyneuropathy. Toxicol Appl Pharmacol. 1993 Oct;122(2):165-71. Review.
Lotti M. The pathogenesis of organophosphate polyneuropathy. Crit Rev Toxicol. 1991;21(6):465-87. Review.
Lotti M, Moretto A. Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitors. Chem Biol Interact. 1999 May 14;119-120:519-24. Review.
Damodaran TV, Abdel-Rahman A, Abou-Donia MB. Altered time course of mRNA expression of alpha tubulin in the central nervous system of hens treated with diisopropyl phosphorofluoridate (DFP). Neurochem Res. 2001 Jan;26(1):43-50.
Xie K, Gupta RP, Abou-Donia MB. Effect of prevention and potentiation of diisopropyl phosphorofluoridate (DFP)-induced delayed neurotoxicity on the mRNA expression of neurofilament subunits in hen central nervous system. Biochem Cell Biol. 2001;79(2):207-17.
Damodaran TV, Rahman AA, Abou-Donia MB. Early differential induction of C-jun in the central nervous system of hens treated with diisopropylphosphorofluoridate (DFP). Neurochem Res. 2000 Dec;25(12):1579-86.
Damodaran TV, Abdel-Rahman A, El-Sourady MH, Abou-Donia MB. Differential alteration of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA in the central nervous system of hens treated with diisopropylphosphorofluoridate (DFP). Neurochem Int. 2002 Apr;40(4):371-9.
Gupta RC, Milatovic D, Dettbarn WD. Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-alpha-phenylnitrone or vitamin E. Arch Toxicol. 2001 Aug;75(6):346-56.
Gupta RP, Abou-Donia MB. Enhanced activity and level of protein kinase A in the spinal cord supernatant of diisopropyl phosphorofluoridate (DFP)-treated hens. Distribution of protein kinases and phosphatases in spinal cord subcellular fractions. Mol Cell Biochem. 2001 Apr;220(1-2):15-23.
Choudhary S, Joshi K, Gill KD. Possible role of enhanced microtubule phosphorylation in dichlorvos induced delayed neurotoxicity in rat. Brain Res. 2001 Apr 6;897(1-2):60-70.
Gupta RP, Abou-Donia MB. Tau proteins-enhanced Ca2+/calmodulin (CaM)-dependent phosphorylation by the brain supernatant of diisopropyl phosphorofluoridate (DFP)-treated hen: tau mutants indicate phosphorylation of more amino acids in tau by CaM kinase II. Brain Res. 1998 Nov 30;813(1):32-43.
Gupta RP, Abou-Donia MB. Tau phosphorylation by diisopropyl phosphorofluoridate (DFP)-treated hen brain supernatant inhibits its binding with microtubules: role of Ca2+/Calmodulin-dependent protein kinase II in tau phosphorylation. Arch Biochem Biophys. 1999 May 15;365(2):268-78.
Gupta RP, Abou-Donia MB. Tau proteins-enhanced Ca2+/calmodulin (CaM)-dependent phosphorylation by the brain supernatant of diisopropyl phosphorofluoridate (DFP)-treated hen: tau mutants indicate phosphorylation of more amino acids in tau by CaM kinase II. Brain Res. 1998 Nov 30;813(1):32-43.
Gupta RP, Bing G, Hong JS, Abou-Donia MB. cDNA cloning and sequencing of Ca2+/calmodulin-dependent protein kinase IIalpha subunit and its mRNA expression in diisopropyl phosphorofluoridate (DFP)-treated hen central nervous system.
Mol Cell Biochem. 1998 Apr;181(1-2):29-39.
Gupta RP, Abou-Donia MB. Neurofilament phosphorylation and [125I]calmodulin binding by Ca2+/calmodulin-dependent protein kinase in the brain subcellular fractions of diisopropyl phosphorofluoridate (DFP)-treated hen. Neurochem Res. 1995 Sep;20(9):1095-105.
Gupta RP, Damodaran TV, Abou-Donia MB. C-fos mRNA induction in the central and peripheral nervous systems of diisopropyl phosphorofluoridate (DFP)-treated hens. Neurochem Res. 2000 Mar;25(3):327-34.
Abou-Donia MB. The cytoskeleton as a target for organophosphorus ester-induced delayed neurotoxicity (OPIDN). Chem Biol Interact. 1993 Jun;87(1-3):383-93. Review.
Abou-Donia MB, Viana ME, Gupta RP, Anderson JK. Enhanced calmodulin binding concurrent with increased kinase-dependent phosphorylation of cytoskeletal proteins following a single subcutaneous injection of diisopropyl phosphorofluoridate in hens. Neurochem Int. 1993 Feb;22(2):165-73.
Lapadula ES, Lapadula DM, Abou-Donia MB. Persistent alterations of calmodulin kinase II activity in chickens after an oral dose of tri-o-cresyl phosphate.
Biochem Pharmacol. 1991 Jun 21;42(1):171-80.
Gupta RP, Abdel-Rahman A, Jensen KF, Abou-Donia MB. Altered expression of neurofilament subunits in diisopropyl phosphorofluoridate-treated hen spinal cord and their presence in axonal aggregations. Brain Res. 2000 Sep 29;878(1-2):32-47.
Damodaran TV, Abou-Donia MB. Alterations in levels of mRNAs coding for glial fibrillary acidic protein (GFAP) and vimentin genes in the central nervous system of hens treated with diisopropyl phosphorofluoridate (DFP). Neurochem Res. 2000 Jun;25(6):809-16.
Gill I, Ballesteros A. Degradation of organophosphorous nerve agents by enzyme-polymer nanocomposites: efficient biocatalytic materials for personal protection and large-scale detoxification. Biotechnol Bioeng. 2000 Nov 20;70(4):400-10
Aschner M. Interactions between pesticides and glia: an unexplored experimental field. Neurotoxicology. 2000 Feb-Apr;21(1-2):175-80. Review.
Katoh K. [A review of studies of the delayed neurotoxicity induced by organophosphorus esters] Sangyo Eiseigaku Zasshi. 1995 Sep;37(5):309-19. Review. Japanese.
Petrikovics I, Cheng TC, Papahadjopoulos D, Hong K, Yin R, DeFrank JJ, Jaing J, Song ZH, McGuinn WD, Sylvester D, Pei L, Madec J, Tamulinas C, Jaszberenyi JC, Barcza T, Way JL. Long circulating liposomes encapsulating organophosphorus acid anhydrolase in diisopropylfluorophosphate antagonism. Toxicol Sci. 2000 Sep;57(1):16-21
Petrovic RM, Jokanovic M, Maksimovic M, Ugresic N, Boskovic B. The treatment of delayed polyneuropathy induced by diisopropylfluorophosphate in hens. Pharmazie. 2000 Jun;55(6):454-5
Petrikovics I, McGuinn WD, Sylvester D, Yuzapavik P, Jiang J, Way JL, Papahadjopoulos D, Hong K, Yin R, Cheng TC, DeFrank JJ. In vitro studies on sterically stabilized liposomes (SL) as enzyme carriers in organophosphorus (OP) antagonism. Drug Deliv. 2000 Apr-Jun;7(2):83-9.
Huggins DJ, Richardson RJ. Brainstem axolemmal protein phosphorylation in vitro in hens dosed with di-1-butyl-2,2-dichlorovinyl phosphate. J Toxicol Environ Health A. 1999 Feb 26;56(4):263-82.
Broide RS, Grifman M, Loewenstein A, Grisaru D, Timberg R, Stone J, Shani M, Patrick JW, Soreq H. Manipulations of ACHE gene expression suggest non-catalytic involvement of acetylcholinesterase in the functioning of mammalian photoreceptors but not in retinal degeneration. Brain Res Mol Brain Res. 1999 Aug 25;71(2):137-48.
Billecke SS, Primo-Parmo SL, Dunlop CS, Doorn JA, La Du BN, Broomfield CA. Characterization of a soluble mouse liver enzyme capable of hydrolyzing diisopropyl phosphorofluoridate. Chem Biol Interact. 1999 May 14;119-120:251-6.
Yen DH, Yen JC, Len WB, Wang LM, Lee CH, Chan SH. Spectral changes in systemic arterial pressure signals during acute mevinphos intoxication in the rat. Shock. 2001 Jan;15(1):35-41
Farage-Elawar M, Blaker WD. Chick embryo exposure to carbamates alters neurochemical parameters and behavior. J Appl Toxicol. 1992 Dec;12(6):421-6
Easton A, Guven K, de Pomerai DI. Toxicity of the dithiocarbamate fungicide mancozeb to the nontarget soil nematode, Caenorhabditis elegans. J Biochem Mol Toxicol. 2001;15(1):15-25.
Guven K, Power RS, Avramides S, Allender R, de Pomerai DI. The toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain of Caenorhabditis elegans. J Biochem Mol Toxicol. 1999;13(6):324-33.
Deveci E, Guven K, Bashan M, Onen A, de Pomerai D. The accumulation and histological effects of organometallic fungicides propineb and maneb in the livers of pregnant rats and their offspring. J Toxicol Sci. 1999 May;24(2):79-85.
Guven K, Deveci E, Akba O, Onen A, de Pomerai D. The accumulation and histological effects of organometallic fungicides Propineb and Maneb in the kidneys of fetus and female rats during pregnancy. Toxicol Lett. 1998 Oct 15;99(2):91-8.
Thrasher JD, Madison R, Broughton A. Immunologic abnormalities in humans exposed to chlorpyrifos: preliminary observations. Arch Environ Health. 1993 Mar-Apr;48(2):89-93.
Thrasher JD, Madison R, Broughton A, Gard Z. Building-related illness and antibodies to albumin conjugates of formaldehyde, toluene diisocyanate, and trimellitic anhydride.
Am J Ind Med. 1989;15(2):187-95.
Hastings L, Evans JE Olfactory primary neurons as a route of entry for toxic agents into the CNS. Neurotoxicology. 1991 Winter;12(4):707-14.
Compston JE, Vedi S, Stephen AB, Bord S, Lyons AR, Hodges SJ, Scammell BE. Reduced bone formation after exposure to organophosphates. Lancet. 1999 Nov 20;354(9192):1791-2.

Pesticides and endocrine disruption

Burow ME, Weldon CB, Tang Y, McLachlan JA, Beckman BS Oestrogen-mediated suppression of tumour necrosis factor alpha-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by anti-oestrogens. J Steroid Biochem Mol Biol. 2001 Nov;78(5):409-18.
Gulledge CC, Burow ME, McLachlan JA. Endocrine disruption in sexual differentiation and puberty. What do pseudohermaphroditic polar bears have to do with the practice of pediatrics? Pediatr Clin North Am. 2001 Oct;48(5):1223-40, x. Review.
Fox JE, Starcevic M, Kow KY, Burow ME, McLachlan JA. Nitrogen fixation. Endocrine disrupters and flavonoid signalling. Nature. 2001 Sep 13;413(6852):128-9.
Collins-Burow BM, Burow ME, Duong BN, McLachlan JA Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms. Nutr Cancer. 2000;38(2):229-44.
McLachlan JA, Newbold RR, Burow ME, Li SF. From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters. APMIS. 2001 Apr;109(4):263-72. Review.
McLachlan JA. Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals. Endocr Rev. 2001 Jun;22(3):319-41. Review.
McLachlan JA, Burow M, Chiang TC, Li SF. Gene imprinting in developmental toxicology: a possible interface between physiology and pathology. Toxicol Lett. 2001 Mar 31;120(1-3):161-4. Review.
Burow ME, Boue SM, Collins-Burow BM, Melnik LI, Duong BN, Carter-Wientjes CH, Li S, Wiese TE, Cleveland TE, McLachlan JA. Phytochemical glyceollins, isolated from soy, mediate antihormonal effects through estrogen receptor alpha and beta. J Clin Endocrinol Metab. 2001 Apr;86(4):1750-8.
Oberdorster E, Brouwer M, Hoexum-Brouwer T, Manning S, McLachlan JA. Long-term pyrene exposure of grass shrimp, Palaemonetes pugio, affects molting and reproduction of exposed males and offspring of exposed females. Environ Health Perspect. 2000 Jul;108(7):641-6.
Newbold RR, Hanson RB, Jefferson WN, Bullock BC, Haseman J, McLachlan JA. Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis. 2000 Jul;21(7):1355-63.
Smallridge RC, Carr FE, Fein HG. Diisopropylfluorophosphate (DFP) reduces serum prolactin, thyrotropin, luteinizing hormone, and growth hormone and increases adrenocorticotropin and corticosterone in rats: involvement of dopaminergic and somatostatinergic as well as cholinergic pathways.
Toxicol Appl Pharmacol. 1991 Apr;108(2):284-95.
Binh PX, Nyakas C, Endroczi E. Changes in the pituitary-adrenocortical function after intracerebral administration of di-isopropyl-fluorophosphate and physostigmine in the rat. Endokrinologie. 1980 Dec;76(3):303-8.
Kokka N, Clemons GK, Lomax P. Effects of the organophosphate cholinesterase inhibitor (DFP) on hypothalamic acetylcholinesterase and pituitary-adrenal activity. Proc West Pharmacol Soc. 1987;30:219-21. No abstract available.
Kokka N, Clemons GK, Lomax P. Relationship between the temperature and endocrine changes induced by cholinesterase inhibitors. Pharmacology. 1987;34(2-3):74-9.
Van de Kar LD, Lorens SA, Urban JH, Richardson KD, Paris J, Bethea CL. Pharmacological studies on stress-induced renin and prolactin secretion: effects of benzodiazepines, naloxone, propranolol and diisopropyl fluorophosphate. Brain Res. 1985 Oct 21;345(2):257-63.
Reeves JD. Household insecticide-associated blood dyscrasias in children.
Am J Pediatr Hematol Oncol. 1982 Winter;4(4):438-9. No abstract available.
Reeves JD, Driggers DA, Kiley VA. Household insecticide associated aplastic anaemia and acute leukaemia in children. Lancet. 1981 Aug 8;2(8241):300-1. No abstract available.
Kolbasin PN, Shpak SI. [Effects of organochlorine and organophosphate pesticides on degranulation of tissue basophils during exertion]
Gig Sanit. 1993 Mar;(3):50-1. Russian. No abstract available.
NICHOLS J, RICHARDSON AW. Effects of DDD on steroid response and blood flow through the adrenal after ACTH. Proc Soc Exp Biol Med. 1960 Aug-Sep;104:539-42. No abstract available.
LARSON PS, HENNIGAR GR, FINNEGAN JK, SMITH RB Jr, HAAG HB. Observations on the relation of chemical structure to the production of adrenal cortical atrophy or hypertrophy in the dog by derivatives of 2, 2-bis-(p-chlorophenyl)-1, 1-dichloroethane (DDD, TDE).
J Pharmacol Exp Ther. 1955 Dec;115(4):408-12. No abstract available.
MARTINEZ C, ZIMMERMANN B Effect of DDD on postcastrational adrenal tumors in mice.
Surg Forum. 1957;8:177-9. No abstract available.
BLOCH HS, HITCHCOCK CR, HOELSCHER B, WILLIAMS WL, ZIMMERMANN B. The effects of DDD (1, 1-dichloro-2, 2-bis-(p-chlorophenyl)ethane) on the human adrenal; attempts to use an adrenal-destructive agent in the treatment of disseminated mammary and prostatic cancer. Cancer. 1956 Sep-Oct;9(5):940-8. No abstract available.

Chronic Fatigue Syndrome/ME/Multiple Chemical Sensitivity

Anderson RC, Anderson JH Respiratory toxicity in mice exposed to mattress covers. Arch Environ Health. 1999 May-Jun;54(3):202-9.

Anderson RC, Anderson JH. Respiratory toxicity of mattress emissions in mice. Arch Environ Health. 2000 Jan-Feb;55(1):38-43.

Anderson RC, Anderson JH. Acute respiratory effects of diaper emissions. Arch Environ Health. 1999 Sep-Oct;54(5):353-8

Anderson RC, Anderson JH. Respiratory toxicity of fabric softener emissions. J Toxicol Environ Health A. 2000 May 26;60(2):121-36.

Anderson RC, Anderson JH Acute toxic effects of fragrance products. Arch Environ Health. 1998 Mar-Apr;53(2):138-46.

Anderson RC, Anderson JH Toxic effects of air freshener emissions. Arch Environ Health. 1997 Nov-Dec;52(6):433-41

Anderson RC, Anderson JH. Acute toxicity of marking pen emissions. J Toxicol Environ Health A. 2003 May 9;66(9):829-45.

Anderson RC, Anderson JH Sensory irritation and multiple chemical sensitivity. Toxicol Ind Health. 1999 Apr-Jun;15(3-4):339-45.

McKeown-Eyssen G, Baines C, Cole DE, Riley N, Tyndale RF, Marshall L, Jazmaji V. Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR. Int J Epidemiol. 2004 Oct;33(5):971-8. Epub 2004 Jul 15.
Naschitz JE, Rosner I, Rozenbaum M, Fields M, Isseroff H, Babich JP, Zuckerman E, Elias N, Yeshurun D, Naschitz S, Sabo E. Patterns of cardiovascular reactivity in disease diagnosis. QJM. 2004 Mar;97(3):141-51.
Naschitz JE, Rosner I, Rozenbaum M, Naschitz S, Musafia-Priselac R, Shaviv N, Fields M, Isseroff H, Zuckerman E, Yeshurun D, Sabo E. The head-up tilt test with haemodynamic instability score in diagnosing chronic fatigue syndrome. QJM. 2003 Feb;96(2):133-42.
Yamamoto Y, LaManca JJ, Natelson BH. A measure of heart rate variability is sensitive to orthostatic challenge in women with chronic fatigue syndrome.
Exp Biol Med (Maywood). 2003 Feb;228(2):167-74.
Naschitz JE, Sabo E, Naschitz S, Rosner I, Rozenbaum M, Fields M, Isseroff H, Priselac RM, Gaitini L, Eldar S, Zukerman E, Yeshurun D, Madelain F, Isseroff H. Hemodynamics instability score in chronic fatigue syndrome and in non-chronic fatigue syndrome. Semin Arthritis Rheum. 2002 Dec;32(3):141-8.Erratum in: Semin Arthritis Rheum. 2003 Apr;32(5):343 Madelain, Fields [corrected to Feilds Madeline]; Hillel, Isseroff [corrected to Isseroff Hillel].
Naschitz JE, Sabo E, Naschitz S, Rosner I, Rozenbaum M, Priselac RM, Gaitini L, Zukerman E, Yeshurun D. Fractal analysis and recurrence quantification analysis of heart rate and pulse transit time for diagnosing chronic fatigue syndrome. Clin Auton Res. 2002 Aug;12(4):264-72.
Timmers HJ, Wieling W, Soetekouw PM, Bleijenberg G, Van Der Meer JW, Lenders JW. Hemodynamic and neurohumoral responses to head-up tilt in patients with chronic fatigue syndrome.
Clin Auton Res. 2002 Aug;12(4):273-80.
Poole J, Herrell R, Ashton S, Goldberg J, Buchwald D. Results of isoproterenol tilt table testing in monozygotic twins discordant for chronic fatigue syndrome.
Arch Intern Med. 2000 Dec 11-25;160(22):3461-8
Stewart JM. Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion. Pediatr Res. 2000 Aug;48(2):218-26.
Stewart JM, Gewitz MH, Weldon A, Munoz J. Patterns of orthostatic intolerance: the orthostatic tachycardia syndrome and adolescent chronic fatigue. J Pediatr. 1999 Aug;135(2 Pt 1):218-25.
Stewart JM, Gewitz MH, Weldon A, Arlievsky N, Li K, Munoz J. Orthostatic intolerance in adolescent chronic fatigue syndrome. Pediatrics. 1999 Jan;103(1):116-21.
Stewart J, Weldon A, Arlievsky N, Li K, Munoz J. Neurally mediated hypotension and autonomic dysfunction measured by heart rate variability during head-up tilt testing in children with chronic fatigue syndrome. Clin Auton Res. 1998 Aug;8(4):221-30.
Schondorf R, Benoit J, Wein T, Phaneuf D. Orthostatic intolerance in the chronic fatigue syndrome. J Auton Nerv Syst. 1999 Feb 15;75(2-3):192-201.
CFS and creatine supplements / Smith SA, Montain SJ, Zientara GP, Fielding RA. Use of phosphocreatine kinetics to determine the influence of creatine on muscle mitochondrial respiration: an in vivo 31P-MRS study of oral creatine ingestion. J Appl Physiol. 2004 Jun;96(6):2288-92. Epub 2004 Feb 20.
Kennedy G, Spence V, Underwood C, Belch JJ. Increased neutrophil apoptosis in chronic fatigue syndrome. J Clin Pathol. 2004 Aug;57(8):891-3.
Spence VA, Khan F, Kennedy G, Abbot NC, Belch JJ. Acetylcholine mediated vasodilatation in the microcirculation of patients with chronic fatigue syndrome.
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RNase L info

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Levine PH, Whiteside TL, Friberg D, Bryant J, Colclough G, Herberman RB. Dysfunction of natural killer activity in a family with chronic fatigue syndrome. Clin Immunol Immunopathol. 1998 Jul;88(1):96-104

Michiels V, Cluydts R, Fischler B, Hoffmann G, Le Bon O, De Meirleir K. Cognitive functioning in patients with chronic fatigue syndrome. J Clin Exp Neuropsychol. 1996 Oct;18(5):666-77.
Fischler B, D'Haenen H, Cluydts R, Michiels V, Demets K, Bossuyt A, Kaufman L, De Meirleir K.Comparison of 99m Tc HMPAO SPECT scan between chronic fatigue syndrome, major depression and healthy controls: an exploratory study of clinical correlates of regional cerebral blood flow. Neuropsychobiology. 1996;34(4):175-83.
De Becker P, McGregor N, De Meirleir K. A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome.
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Le Bon O, Hoffmann G, Murphy J, De Meirleir K, Cluydts R, Pelc I. How significant are primary sleep disorders and sleepiness in the chronic fatigue syndrome? Sleep Res Online. 2000;3(2):43-8.

De Becker P, Roeykens J, Reynders M, McGregor N, De Meirleir K. Exercise capacity in chronic fatigue syndrome. Arch Intern Med. 2000 Nov 27;160(21):3270-7.
De Meirleir K, Bisbal C, Campine I, De Becker P, Salehzada T, Demettre E, Lebleu B. A 37 kDa 2-5A binding protein as a potential biochemical marker for chronic fatigue syndrome.
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De Becker P, De Meirleir K, Joos E, Campine I, Van Steenberge E, Smitz J, Velkeniers B. Dehydroepiandrosterone (DHEA) response to i.v. ACTH in patients with chronic fatigue syndrome. Horm Metab Res. 1999 Jan;31(1):18-21.

De Becker P, Dendale P, De Meirleir K, Campine I, Vandenborne K, Hagers Y. Autonomic testing in patients with chronic fatigue syndrome. Am J Med. 1998 Sep 28;105(3A):22S-26S.

Suhadolnik RJ, Peterson DL, O'Brien K, Cheney PR, Herst CV, Reichenbach NL, Kon N, Horvath SE, Iacono KT, Adelson ME, De Meirleir K, De Becker P, Charubala R, Pfleiderer W. Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome. J Interferon Cytokine Res. 1997 Jul;17(7):377-85.