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REFERENCES

  1. Purdey M. Are organo-phosphate pesticides involved in the causation of BSE? Hypothesis based upon a literature review and limited trials on BSE cattle. J Nutri Med 1994; 4 (1) 43-82.
  2. Purdey M. The UK epidemic of BSE; Slow virus or chronic pesticide initiated modification of the prion protein. (Pts 1 and 2). Med Hypotheses 1996; 46 : 429-454.
  3. Mena I. Manganese. In Disorders of Mineral Metabolism, Vol. 1 Trace minerals. Bronner F. Ford E.D., eds, New York: Academic Press, 1981:233-270.
  4. Mertz W., ed. Trace Elements in Human and Animal Nutrition. New York: Academic Press, 1986.
  5. Smith C., Clarke A.R. Structural properties of PrP. In: Collinge J., Palmer M.S., eds. Prion Diseases. Oxford: Oxford University Press, 1997; 177-194.
  6. Banta R.C., Markesbury W.R. Elevated Mn levels associated with dementia and extrapyramidal signs. Neurology 1977; 27 : 213-216.
  7. Aschner M., Aschner J.L. Manganese neurotoxicity; Cellular effects and blood brain barrier transport. Neurosci Biobehavioral Revs 1991; 15 : 333-340.
  8. Flynn A., Franzmann A.W., Arneson P.D., Oldemeyer J.L. Indications of Cu deficiency in a subpopulation of Alaskan Moose. J Nutri 1977; 107 : 1182-1189.
  9. Gianutsos G., Morrow G.R., Morris J.B. Accumulation of Mn in rat brain following intranasal administration. Fund Appi Toxicol 1997; 37 (2): 102-105.
  10. Halliwell B., Gutteridge J.M.C., eds. Free Radicals in Biology and Medicine, Oxford: Clarendon Press, 1989.
  11. Barbeau A. Manganese and extra pyramidal disorders. Neurotoxicol 1984; 5 : (1) 13-36.
  12. Karlin S., Zhan-Yang Z., Karlin K.D. The extended environment of mononuclear metal centres in protein structures. Proc Nati AcadSci USA 1997; 94 : 14225-14230.
  13. Bocchetta A., Corsini G.U. Parkinsons disease and pesticides. Lancet 1986; 11 : 1163.
  14. Grcevic N., Jadro-Santel D., Jukic S. In: Roizin L, Shiraki H., Grcevic N., eds Neurotoxicology New York: Raven Press, 1977; 469-484.
  15. Brown D., Qin K., Herms J. et al. The cellular prion protein binds copper in vivo. Nature 1997; 390 : 684-687.
  16. Tanner C.M. The role of environmental toxins in the etiology of Parkinsons disease. TINS 1989; 12 (2): 49-54.
  17. Hassall K.A. The Chemistry of Pesticides. London: Macmillan Press, 1982.
  18. Cashman N.R., Loertscher R., Nalbantoglu J et al. cellular isoform of the scrapie agent protein participates in lymphocyte activation. Cell 1990; 61 : 185-192.
  19. Rutter G., Asher D.M., Rohwer R.G. et al. Increased concanavalin A capping in cells from brains of scrapie infected hamsters. Arch Neurol 1981; 68 : 129-133.
  20. Venturini G. Enzyme activities and Na, K and Cu concentrations in mouse brain and liver after cuprizone treatment in vivo. J Neurochem 1973; 21 : 1147-1151.
  21. Purves D.C., Garrod I.J., Dayan A.D. A comparison of the spongiosis induced in the brain by hexachlorophene, cuprizone and triethyl tin in the Sprague Dawley rat. Human Experimental Toxicol 1991; 10 (6): 439-444.
  22. Cooper J.R., Bloom F.E., Roth R.H. The Biochemical Basis of Neuropharmacology, 7th edn. Oxford: Oxford University Press, 1990.
  23. Pattison I.H., Jebbett J.N. Spongiform encephalopathy induced in rats and guinea pigs by cuprizone. Exp Mol Pathol 1969; 10 (3): 274-287.
  24. Allain P., Krari N. diethyldithiocarbamate, copper and neurological disorders. Life Sci 1991; 48 : 291-299.
  25. Edington N., Howell JMcC. The neurotoxicity of Sodium Diethyldithiocarbamate in the rabbit. Acta Neuropathol (Berl) 1969;12 :339-347
  26. Hoogenraad T.U. dithiocarbamates and Parkinson's disease. Lancet 1988; 1 : 767
  27. Laplane D., Attal N., Sauron B., de Billy A., Dubois B. Lesions of basal ganglia due to disulfiram neurotoxicity. J Neural Neumsurg Psychiatry 1992; 55 : 925-929.
  28. Meco G., Bonifati V., Vanacore N., Fabrizio E. Parkinsonism after chronic exposure to the fungicide maneb. Scand J Work Environ Health 1994; 28 : 301-305.
  29. Cho H., Greig A., Corp C., Kimberlin R., Chandler R. Nature (London)1977; 267 : 459-460.
  30. Radhakrishnamurthy B., Rucker R., Berenson G. Proc Soc Exp Biol Med. 1985; 180 : 392.
  31. MAFF. Trace Elements in Soils and Crops; Proceedings of a conference organised by Soil Scientists of the NAAS. Feb 8-9th 1966. Technical Bulletin 21. London: HMSO 1971.
  32. Brown D.B., Schmidt B., Kretzschmar H.A. Effects of oxidative stress on Prp expression in PC 12 cells. Int J Devl Neurosci 1997; 15 (8): 961-972.
  33. Brown D., Schulz-Schaeffer W.J., Schmidt B., Kretzschmar H.A. PrP deficient cells show altered response to oxidative stress due to decreased SOD-1 activity. Experimental Neural 1997; 146 :104-112.
  34. Hornshaw M., McDermott ]., Candy ]., Lakey J. Copper binding to the N-terminal tandem repeat region of mammalian and avian PrP; Structural studies using synthetic peptides. Biochem Biophysical Res Commun 1995; 214 (3): 993-999.
  35. Thompsett S.L. Biochem J 1940; 34 : 461.
  36. Cohen D.I., Illowsky B., Linder M.C. Am J Physiol 1979; 236 : E309.
  37. Henkin R.I. In: Hoekstra W.G., Suttie J.W., Ganther H.E., Mertz W., eds. Trace Elements Metabolism in Animals. Baltimore: University Park Press, 1974: 647
  38. Beauregard G., Lum J., Roufogalis B. Effect of histidine modification on the aging of OP-inhibited acetylcholinesterase. Biochem &nbspPharmacol 1981; 30(21): 2915-2920.
  39. Dallocchio F., Matteuzzi, Bellini T. Non enzymic protein phosphorylation. Biochem J 1982; 203 : 401-404.
  40. Brown D.R., Besinger A. Prion protein expression and superoxide dismutase activity. Biochem J 1998; 334 : 423-429.
  41. Bastian F. CJD and Other Transmissible Spongiform Encephalopathies. St Louis: Mosby Year Book, 1991.
  42. De Reuck J., De Coster W., vander Eecken H. CJD; a comparative light-microscopic, histochemical and electron microscopic study. Eur Neurol 1975; 13 : 154-166.
  43. Whatley S.A., PowellJ.F., Politopoulou G., Campbell I.e., Brammer M.J., Percy N.S. Regulation of intracellular free calcium levels by the cellular prion protein. Mol Neurosci 1995; 6 :2333-2337
  44. Kristensson K., Feuerstein B., Taraboulos A., Hyun M., Prusiner S., DeArmond S. Scrapie prions alter receptor-mediated calcium responses in cultured cells. Neurol 1993; 43 : 2335-2341
  45. Robinson N; CJD: a histochemical study. Brain 1969; 92 : 581-588.
  46. Mackensie A. Intraneuronal enzymic inclusions in the histological diagnosis of scrapie. J Comp Path 1984; 94 : 9-24.
  47. Ikuta F, Kumanishi T, Qhashi T. Experimental study on CJD. Adv Neurol Sci 1974; 18 : 46-61.
  48. Narang H., Millar N., Asher D., Gajdusek D. Increased multimeric mitochondrial DNA in the brain of scrapie-infected hamsters. Intervirology 1991; 32 : 316-324.
  49. Dowson J. Neuronal lipofuscin accumulation in ageing and Alzheimer's dementia; a pathogenic mechanism? Br J Psychiatry 1982; 140 : 142-148.
  50. Snyder S.H., Bredt D.S. Biological roles of nitric oxide. Sci Am 1992; May: 28-35.
  51. Forman H., Cadenas E., eds. Oxidative Stress and Signal transduction. New York: Chapman and Hall, 1997.
  52. Wallace D.C. Mitochondrial DNA in Aging and disease. Sci Am 1997; August: 22-29.
  53. Ying W. Deleterious network hypothesis of Alzheimer's disease. Med Hypotheses 1996; 46 : 421-423.
  54. Panic B., Bezbradica L.J., Nedeljkov N., Istwani A.G. In: Hoekstra W.G., Suttie J.W., Granther H.E., Mertz W., eds. Trace Element Metabolism in Animals. Vol. 2. Baltimore: University Park Press, 1974: 635.
  55. Carruthers M.E., Hobbs C.B., Warren R.L. Raised ceruloplasmin levels in subjects taking oral contraceptives. J Clin Pathol 1966; 19 :498-500.
  56. Mckinley M.P., Longo F.M., Valletta J.S. Nerve growth factor induces gene expression of the prion protein and amyloid protein precursor in the developing hamster central nervous system. Prog Brain Res 1990; 86 : 227-237.
  57. Williams E.S., Young S. Spongiform encephalopathies in Cervidae. Rev Sci Tech Off Int Epiz 1992; 11 (2): 551-567.
  58. Spraker T.R., Miller M.W, Williams E.S. et al. Spongiform encephalopathy in free ranging Mule deer, White-tailed deer and Rocky Mountain Elk in NorthCentral Colorado. J Wildlife Diseases 1997; 33 (1): 1-6.
  59. Palsson P.A. ed. Rida (scrapie) in Iceland and its epidemiology; In: Slow Transmissible Diseases of the Nervous System, Vol. 1. New York: Academic Press, 1979: 357-366.
  60. Sigurdarson S. Epidemiology of scrapie in Iceland and experience with control measures. In: Bradley R., ed. Sub Acute Spongiform Encephalopathies, Brussels and Luxembourg: ECSC EEC EAEC, 1991: 233-242.
  61. Mitrova E. Some new aspects of CJD epidemiology in Slovakia. Eur J Epidemiol 1991; 7 (5): 439-449.
  62. Mayer V., Orolin D., Mitrova E., Lehotsky T. Transmissible virus dementia. 1. An unusual space and time clustering of CJD and of other organic presenile dementia cases. Acta Virol 1978; 22 : 146-153.
  63. Mitrova E., Bronis M. Clusters of CJD in Slovakia: the first statistically significant temporo-spatial accumulations of rural cases. Eur J Epidemiol 1991; 7 (5): 450-456.
  64. Mitrova E.. Brown P., Hroncova D., Tatara M., ZilakJ. Focal accumulation of CJD in Slovakia: retrospective investigation of a new familial cluster. Eur J Epidemiol 1991; 7 (5): 487-489.
  65. Loue A. La nutrition minerale du cafeier en Cote d'lvoire (Centre de Recherches Agronomiques de Bingerville) 1957.
  66. Hidiroglou M., Ivan M., Bryan M.K. et al. Assessment of the role of manganese in congenital joint laxity and dwarfism in calves. Ann Rech Vet 1990: 21 (4): 281-284.
  67. Jaworski A., Skrzyszewski J. Acta Agrar Silvestria Ser Silvestris 1988; 27 (0): 85-96.
  68. Mitrova E., Huncaga S., Hocman G. Clusters of CJD in Slovakia 11; The first evidence of scrapie in Czecko-Slovakia. Eur J Epidemiol 1991; 7 (5).
  69. McDonald P., Edwards R.A., Greenhalgh J.F.D. Animal Nutrition, 2nd edn. London: Longman, 1973.
  70. Maslenova D. Analyses of Water sources serving Hybe, Lipt Sielnica and Dubrava. Vysledky Rozborov. 1998, SZU Sturova 36, 031 80 Liptovsky Mikulas, Slovakia.
  71. Ranostajova K. Analyses of metal levels in hair of children in Dolny Kubin and Oravska Lesna, 1983/1987/1995. Stanovenie Tazkych Kovov Vo Vlasoch Deti V OkreseDolny Kubin. SZU Nemocnicna 12, Dolny Kubin, Slovakia.
  72. Clemens E.T, Meyer K.L, Carlson M.P., Schneider N.R. Hematology, blood chemistry and selenium values of captive pronghom antelope, white tailed deer and american bison. Camp Biochem Physiol 1987; 87C (1): 167-170.
  73. Frick C. Horned ruminants of N America. Bull Am Mus Nat Hist 1937; 69 : 1-699.
  74. Barghigiani C., Bargagli R., Siegel B., Siegel S. Source and selectivity in the accumulation of Hg and other metals by plants on Mt Etna. Water Air Soil Pollut 1988; 39 (3/4): 395-408.
  75. Lai J.C.K, Guest J.F., Leung T.K.C., Lim L, Davison A.N. The effects of cadmium, aluminium and manganese on Na-K-activated and Mg activated adenosine triphosphatase activity and choline uptake in rat brain synaptosomes. Biochem Pharmacol 1980; 29 : 141-146.
  76. SEAC, TSEs; A summary of present knowledge and research Sept 1994. London: HMSO.
  77. Hatano S., Nishi Y., Usui T. Am J Clin Nutr 1983; 37 : 457.
  78. Miller S.T, Cotzias G.C., Evert H.A. Am J Physiol 1975; 229 : 1080.
  79. Mena I. The role of manganese in human diseases. Ann Clin Lab Sci 1974; 4: 487-491.
  80. Schroeder HA., Balassa J.J., Tipton I.H. Essential trace metals in man; Mn a study in homeostatis. J Chronic Dis 1966; 19 :545-571.
  81. Collinge J., Sidle K.C.L, Meads J., Ironside J., Hill A.F. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 1996; 383 : 685-690.
  82. Gavin C.E., Gunter K.K., Gunter T.E. Manganese and calcium efflux kinetics in brain mitochondria - relevance to Mn toxicity. Biochem J 1990; 266 : 329-334.
  83. Gibbons R.A., Dixon S.N., Hallis K., RusseU A.M, Sansom B.F., Symonds H.W. Mn metabolism in cows and goats. Biochim Biophys Acta 1976; 444 : 1-10.
  84. Hinks L.J., Clayton B.E., LLoyd R.S. Zn and Cu concentrations in leucocytes and erythrocytes in healthy adults and the effect of oral contraceptives. J Clin Pathol 1983; 36 : 1016-1021.
  85. Kimmerle G., Loeser E. Delayed neurotoxicity of OP compounds and Cu concentrations in the serum of hens. Environ Qual Safetey 1974; 3 : 173-178.
  86. Neff N.H., Barren R.E., Costa E. Selective depletion of caudate nucleus dopamine and serotonin during chronic Mn dioxide administration to squirrel monkeys. Experientia 1969; 25 : 1140-1141.
  87. Mustafa S.J., Chandra S.V. levels of 5-hyroxytryptamine, dopamine and norepinephrine in whole brain of rabbits in chronic Mn toxicity.
  88. Bassant M.H., Picard M., Olichon D., Cathala F., Court L. Changes in the serotonergic, noradrenergic and dopaminergic levels in the brain of scrapie-infected rats. Brain Res 1986; 367 : 360-363.
  89. Cross AJ., Kimberlin R.H., Crow T.J., Johnson J.A, Walker C.A. Neurotransminer metabolites, enzymes and receptors in experimental scrapie. J Neurol Sci 1985; 70 : 231-241.
  90. Brun A., Gottfries C.G., Roos B.E. Studies of the monoamine metabolism in the CNS in CJD. Acta Neurol Scand 1971; 47 : 642-645.
  91. Nyberg P., Almay B.G.L., Carlsson A., Masters C, Winblad B. Brain monamine abnormalities in two types of CJD. Acta Neural Scand 1982; 66 : 16-24.
  92. Goudsmit J., Rohwer R.G., Silvergeld E.K. Hypersensitivity to central serotonin receptor activation in scrapie infected hamsters and the effect of serotonergic drugs on scrapie symptoms. Brain Res 1981; 220 : 372-377.
  93. Weiner W.J, Nausieda P.A, Klawans H.L The effect of levodopa, lergotrile and bromocriptine on brain iron, manganese and copper. Neurology 1978; 28 : 734-737.
  94. Huang C.C., Chu N.S., Lu C.S. et al. Chronic manganese intoxication. Arch Neurol 1989; 46 : 1104-1106.
  95. Bonilla E. Increased GABA content in caudate nucleus of rats after chronic Mn chloride administration. J Neurochem 1978; 31 :51,552.
  96. Jefferys J.G.R. Neurophysiology of prion diseases. In: Collinge J., Palmer M.S., eds Prion Diseases. Oxford: Oxford University Press, 1997: 163-176.
  97. Abdel Naby S., Hassanein M. Neuropsychiatric manifestations of chronic manganese poisoning. J Neural Neurosurg Psychiat 1965; 28 :282-288.
  98. Israeli R., Sculsky M., Tiberin P. Acute CNS changes due to intoxication by manzidan. Toxicology in the use, misuse and abuse of food, drugs and chemicals. Arch Toxicol 1983; Suppl 6 : 238-243.
  99. Abdel Naby S., Kayed K.S, Aref M.A. EEG induced fast activity in chronic Mn poisoning. Acta Neural Scand 1964; 40 (3):259-268.
  100. Ashizawa R. Ueber einen Sektionsfall von chronischer manganvergiftungen. Jap J Med Sci Trans, sect V111 Intern Med Pediat and Psychiat 1927; 1 : 173-191.
  101. Trendtel F. Zur Frage des Manganismus Mschr Unfallheilk 1936; 43 : 69-84.
  102. Canavan M.M., Cobb S., Drinker C.K. Chronic Manganese poisoning; report of a case with autopsy. Arch Neurol Psychiat (Chicago) 1934; 32 : 501-412.
  103. Lasmezas C.I., Deslys J-P., Robain 0. et al. Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein. Science 1997; 275 : 402-403.
  104. Mena I., Marin 0., Fuenzalida S., Cotzias G.C. Chronic Manganese poisoning. Neurol 1967; 17 : 128-136.
  105. Rawal M.L. Manganese poisoning in Mn mines in India. Ind J Industrial Med 1968; 14(2): 41-51.
  106. Will R.G., Ironside J.W., Zeidler M. et al. A new variant of CJD in the UK. Lancet 1996; 347 : 921-925.
  107. Alpers M., Kuru. In: Attenborough R.D., Alpers M., eds. Human Biology in Papua New Guinea. Oxford: Clarendon Press, 1992:312-333.
  108. Greenhouse A.H. Mn intoxication in the USA. Trans Am Neurol Ass 1971; 96 : 248-249.
  109. Denton M.D., Ginsburg A. Conformational changes in glutamine synthetase from Escherichia coli. 1. The binding of Mn in relation to some aspects of the enzyme structure and activity. Biochemistry 1969; 8(4): 1714-1725.
  110. Daniels A.L, Johnson L.N., Williams RJP. Uptake of manganese by chromaffin granules in vitro. J Neurochem 1979; 33: 923-929.
  111. Brown D.B., Schmidt B., Kretzschmar H.A. A PrP fragment primes Type 1 astrocytes to proliferation signals from microglia. Neurobiol of Diseases 1998; 4: 410-422.
  112. Cotzias C.G., Horiouchi K., Fuenzalida S., Mena I. Chronic Mn poisoning; clearance of tissue Mn concentrations with persistence of the neurological picture. Neurol 1968; 18: 376-382
  113. Plaitakis A., Caroscio J.T. Abnormal glutamate metabolism in ALS. Ann Neural 1987; 22: 575-579.
  114. Couratier P., Hugon J., Sindou P., Vallat J.M., Dumas M. Cell culture for neuronal degeneration in ALS being linked to glutamate AMPA/kainate receptors. Lancet 1993; 341: 265-268.
  115. Yase Y. The pathogenesis of ALS. Lancet 1972; 11: 292-296.
  116. Lis H., Sharon N. In: Marous A., ed. The Biochemistry of Plants New York: Academic Press, 1981: 371.
  117. Gershwin M.E., Beach R., Hurley L.S., eds. In: Nutrition and Immunity. Oriando, FL: Academic Press, 1985.
  118. Bartol F., Wiley A., Goodlett D. Ovine uterine morphogenesis; Histochemical aspects of endometrial development in the fetus and neonate. J Amin Sci 1988; 66(5): 1303-1313.
  119. 'Usage of raw materials in Animal feeds in Great Britain 1984-1995', or personal letters - Alex Clothier, MAFF Statistics, Foss House, Kings Pool, 1-2 Peashohne Green, York, Y01 2PX, UK.
  120. Shiraki H., Yase Y., ALS in Japan, In: Vinken PJ., Bruyn G.W., eds. Handbook of Clinical Neurology Amsterdam: North Holland, 1975; 353-410.
  121. Chen K.M. Disappearance of ALS from Guam; implications for exogenous causes Rinsho-shinkeigaku 1995; 35(12): 1549-1553.
  122. Donaldson J. The physiopathologic significance of manganese in brain; its relation to schizophrenia and neurodengereative disorders Neurotoxicology 1987; 8: 451-562.
  123. Yanagihara R. Heavy metals and essential minerals in motor neurone disease. In: Rowland L.P., ed. Human Motor Neurone Diseases. New York: Raven Press, 1982: 233-247.
  124. Calne D.B., Eisen A., McGeer E., Spencer P. AD, PD and MND; abiotrophic interaction between aging and environment. Lancet 1986; 1067-1070.
  125. Muller W.K. Experimental studies on several aspects of MS in Iceland Research Institute Nedri As, Hveragerdi, Iceland, Bulletin 31. Hveragerdi 1979.
  126. Gajdusek D.C. Hypothesis; Interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the CNS. N Engl J Med 1985; 14: 714-719.
  127. Roikhel V., Fokina G., Khokhlov A. Alterations of arginase activity in scrapie-infected mice and in amyotrophic lateral sclerosis. Acta Virol 1990; 34: 545-553.
  128. Cutlip R.C., Miller J.M., Race R.E. Intracerebral transmission of scrapie to cattle. J Infect Dis 1984; 169: 814-820.
  129. Ironside J.W. Bell J.E. Pathology of Prion Diseases, In: Collinge J., Palmer M.S., eds. Prion diseases. Oxford: Oxford University Press, 1997: 87-88.
  130. Approved Products for Farmers and Growers 1985. Refbook 380 (85). 1985. MAFF Publications, London SE99 7TP.
  131. Sly J.M.A. Review of usage of pesticides in Agriculture and horticulture in England and Wales 1975-1979. Report No 23; 1981. MAFF Publications, London SE99 7TP.
  132. Sly J.M.A. (Agricultural Development and Advisory Service, Hatching Green, Harpenden, Herts.) Review of usage of pesticides in Agriculture and horticulture in the UK; Report No 41; Feb 1985. MAFF publications, London. SE 99 7TP.
  133. Thomas M.R. Review of usage of pesticides in Agriculture and horticulture throughout G.B. 1984-1994. Pesticide usage survey report 100. 1997 MAFF Publications London SE99 7TP.
  134. Chemoff N., Kavlock R.J., Rogers E.H., Carver B.D.. Murray S. The teratogenicity of maneb. J Toxic Environ Hlth 1979: 5: 821.
  135. Trace minerals; Manganese. Roche 'Vitec' information sheet Al 4/1 May 1987
  136. Barrett J.W.H., Peterson S.M., Batley G.E. The impact of pesticides on the riverine environment with specific references to cotton growing. The Cotton Research and development corporation and the land and water resources research and development corporation. December 1991, 49.
  137. Hughes E.R., Cotzias G.C. Am J Physiol 1961; 201: 1061.
  138. Cotzias G.C. Manganese in health and disease. Physiol Rev 1958: 38: 503-532.
  139. Hughes E.R., Miller S.T, Cotzias G.C. Am J Physiol 1966; 211: 207.
  140. Sunderman P., Nomoto S., Pradhan A.M., Levine H., Bernstein S.H., Hirsch R. Increased concentration of serum nickel after acute myocardial infarction. New Eng J Med 1970; 283: 896-899.
  141. Long J.B., Holaday J.W. Blood brain barrier; endogenous modulation by adrenal corticol function Science 1985; 227: 1580-1583.
  142. Reid A.C., Teasdale G.M., McCulloch J. Hormonal influence on water permeability across the blood brain barrier. Clin Exp Neurol 1983; 19: 50-53.
  143. Greger J.L., Balingen P., Abernathy R.P., Bennett O.A., Peterson T., Am J Clin Nutri 1978; 31: 117.
  144. Kirchgessner M., Schwarz F.J., Roth Maier D.A. In: Howell J.M., Gawthorne J.M., White C.L, eds. Trace Element Metabolism in Animals and Man. Canberra: Australian Academy of Sciences, 1981:85.
  145. Wilesmith J.W., Ryan J.B.M., Atkinson M.J. BSE: epidemiological studies on the origin. Vet Record 1991; 128: 199-203.
  146. Masters C.L., Harris J.O., Gajdusek C., Gibbs C.J., Bernoulli C., Asher D.M. CJD: Patterns of worldwide occurrence and the significance of familial and sporadic clustering. Ann Neurol 1979; 5: 177-188.
  147. Galvez S.G., Masters C., Gadjusek C., Descriptive epidemiology of CJD in Chile. Arch Neurol 1980; 37: 11-14.
  148. Singhal B.S., Dastur D.K. CJD in Western India. Neuroepidemiol 1983; 2: 93-100.
  149. Cotzias G.C. Manganese. In: Comar C.L., Bronner F., eds. Mineral Metabolism: An Advanced Treatise. New York: Academic Press, 1962: 403-442.
  150. Purdey M. High dose exposure to systemic phosmet insecticide modifies the phosphatidylinositol anchor on the prion protein; the origins of new variant transmissible spongiform encephalopathies. Med Hypotheses 1998; 50: 91-111.
  151. MAFF. BSE in Great Britain. A progress report. December 1997. MAFF Publications, London SE99 72P.
  152. MAFF. Annual Animal Health Report 1982/1983. MAFF Publications, London SE99 72P.
  153. Phthalophos No 46; p 1-21; from series 'Scientific reviews of Soviet literature on toxicity and hazards of chemicals' USSR State Committee for Science and Technology, 1983, Ed; Izmerov N.F. Published by 'United Nations Environment Programme'.
  154. Goldstein A., Aronow L., Kalman S.M. Principles of drug action. In: Basis of Pharmacology, 2nd edn. Wiley International Edition. New York: John Wiley, 1974.
  155. Gordon I., Abdulla E., Campbell I., Whatley S. Phosmet induces up-regulation of the surface expression of prion protein. Neuroreport May 1998.
  156. De Reuck J., Colardyn J.B., Willems J. Fatal encephalopathy in acute poisonings with O.P. insecticides. Clin Neurol Neurosurg 1979; 81(4): 249-254.
  157. Englund G., Pesticides. In: Minckler J., ed. Pathology of the Nervous System 2. New York: McGraw Hill, 1971: 1691.
  158. Martson L.V., Voronina V.M. Experimental study of the effect of a series of phophoroorganic pesticides (Dipterex and Imidan) on embryogenesis. Environ Health Perspectives 1976; 13: 121-125.
  159. Carlton W.W. Studies on the induction of hydrocephalus and spongy degeneration by cuprizone. Lfe Sci 1967; 6 (1): 11-19.
  160. Ecobichon D.J. Pesticides and neurological disease. Boca Raton, FL: CRC Press, 1982: 181.
  161. Dambska M. Blood brain barrier in young rabbit brain after dichlorvos intoxication. Neuropat Pol 1984; 22: 129-137
  162. Patel B.N., David S. A novel GPI anchored form of ceruloplasmin expressed by astrocytes. J Biol Chem 1997; 272(32): 20185-20190.
  163. Malik J., Srivastava A. Studies on the interaction between manganese and fenitrothion in rats. Toxicol Lett 1987; 36: 221-226.
  164. Deimling M., Schnell R. Manganese prolongation of pentobarbital hypnosis in the male rat. Experientia 1981; 37: 1322-1323.
  165. Maines M., Kappas A. Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions. Biochem J 1976; 154: 125-131.
  166. Bakanov S., Amirov B., Nurmagambetov T., Piotrovski S., Kuanysheva T., Korolkova K. Metabolism of the pesticide trichlorometaphos-3 and its effect on the liver monooxygenase system of rats deficient in essential nutrients. Voprosy Meditsinskoi Khimii 1986; 32 (4): 98-102.
  167. Yang Z.P, Morrow J., Aiping W., Roberts L., Dettbarn W.D. Diispropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo. Biochem Pharmacol 1996; 52: 357-361.
  168. Bagchi D., Bagchi M., Hassoun E., Stohs S. In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology 1995; 104: 129-140.
  169. Myshkin V., Vakarina A., Bashkatov S., Sofronov G., Enikeev D. Postintoxication hypothermia and free radical lipid oxidation in the brain and heart of rats poisoned with OP cholinesterase inhibitors. Bull Exper Biol Med 1992; 113 (5): 493-494.
  170. Hai D., Varga S., Matkovics B. OP effects on antioxidant system of carp and catfish. Comp Biochem Physiol 1997; 117C(1): 83-85.
  171. Matkovics B., Szabo L., Mindszenty L., Ivan J. The effects of OP pesticides on some liver enzymes and lipid peroxidation. Gen Pharmac 1980; 11: 353-355.
  172. Chopra A., Ahuja S., Gupta P., Nagpal S. Histopathological and lipid changes in various organs of chicks caused by acute and chronic toxicity of metasystox-R and Lebaycid. Zbl Vet Med A 1979; 26: 822-834.
  173. Akai ]., Ishihara 0., Higuchi S. CJD in Japan. Neuroepidemiology 1989; 8: 32-37.
  174. Collins S., Law M.G., Fletcher A., Boyd A., Caldor J., Masters C.J. Surgical treatment and risk of sporadic CJD; a case control study. Lancet 1999; 353: 693-697.
  175. D'Alessandro M., Petraroli R., Ladogana A., Pocchiari M. High incidence of CJD in rural Calabria, Italy. Lancet 1998; 352: 1989-1990.
  176. Will R.G., Matthews W.B., Smith P.G. A retrospective study of CJD in England and Wales. 1970-1979. 11 Epidemiology. J Neurol Neurosurg Psychiatry 1986; 49: 749-755.
  177. Maps of the hop growing parishes of England. Morris Hanbury Jackson Lemay Ltd, Nettlestead Oast, Paddockwood, Kent, UK.
  178. 1980.Garthwaite D.G., Thomas M.R., Davis R.P. Hops 1987. Pesticide usage survey report 71. PB 0479. 1991; MAFF Publications, London SE99 7TP
  179. Thomas R.E., Garthwaite D.G., Thomas M.R. Hops 1992. Pesticide usage survey report 116. PB 1906. 1994. MAFF Publications, London SE99 7TP
Medical Hypotheses (2000)54(2), 278-306
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